کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2201253 1100007 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stem cell therapy in stroke: Designing clinical trials
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Stem cell therapy in stroke: Designing clinical trials
چکیده انگلیسی

Stroke is a common and disabling condition that represents a potentially attractive target for regenerative therapy. Stem cells from a wide range of origins have been investigated in studies using animal models of stroke, with evidence that neural or mesenchymal cells migrate to the site of ischemic injury after intravascular or intraparenchymal delivery, and that a proportion of cells survive and differentiate into cells with characteristics of neurons or glia. In some studies there is evidence of electrical function of transplanted cells. Some studies report improvements in neurological function with cell implantation even when undertaken up to 30 days after the stroke is induced. Few clinical trials have been undertaken to date, with two studies of a teratocarcinoma-derived cell line delivered by direct brain injection, and two of bone-marrow derived mesenchymal stem cells delivered intravascularly. Ongoing trials of other cell lines are exploring safety. There are considerable difficulties in designing future efficacy trials, some being generic to the field of regenerative treatment in stroke, and some that are specific to stem cells or their mode of delivery.


► Stem cells improve functional outcome in animal models of stroke.
► Some evidence of cell migration, survival and neural differentiation in animal models.
► Few clinical trials have been undertaken, mostly of safety in chronic phase.
► Clinical trials need to consider appropriate patient selection, biomarkers, and outcome measures.
► Cell characteristics and mode of delivery will dictate treatment timing and study design.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 59, Issue 3, September 2011, Pages 367–370
نویسندگان
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