کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2201389 1100017 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Animal model of mania induced by ouabain: Evidence of oxidative stress in submitochondrial particles of the rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Animal model of mania induced by ouabain: Evidence of oxidative stress in submitochondrial particles of the rat brain
چکیده انگلیسی

The intracerebroventricular (ICV) administration of ouabain (a Na+/K+-ATPase inhibitor) in rats has been suggested to mimic some symptoms of human bipolar mania. Clinical studies have shown that bipolar disorder may be related to mitochondrial dysfunction. Herein, we investigated the behavioral and biochemical effects induced by the ICV administration of ouabain in rats. To achieve this aim, the effects of ouabain injection immediately after and 7 days following a single ICV administration (at concentrations of 10−2 and 10−3 M) on locomotion was measured using the open-field test. Additionally, thiobarbituric acid reactive substances (TBARSs) and superoxide production were measured in submitochondrial particles of the prefrontal cortex, hippocampus, striatum and amygdala. Our findings demonstrated that ouabain at 10−2 and 10−3 M induced hyperlocomotion in rats, and this response remained up to 7 days following a single ICV injection. In addition, we observed that the persistent increase in the rat spontaneous locomotion is associated with increased TBARS levels and superoxide generation in submitochondrial particles in the prefrontal cortex, striatum and amygdala. In conclusion, ouabain-induced mania-like behavior may provide a useful animal model to test the hypothesis of the involvement of oxidative stress in bipolar disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 55, Issue 7, December 2009, Pages 491–495
نویسندگان
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