کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2202815 1100395 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development
چکیده انگلیسی

Class 3 secreted semaphorins (Sema3A–3G) participate in many aspects of axon guidance through holoreceptor complexes that include Neuropilin-1 (Npn-1) or Neuropilin-2 and one of the four class A plexin proteins. However, unlike other Sema3 family proteins, Sema3E directly binds to Plexin-D1 without neuropilins. Its biological function was first explored in intersomitic vessel formation and since its initial discovery, Sema3E–Plexin-D1 signaling has been found to participate in the many biological systems in addition to vascular development, via seemingly different mode of actions. For example, temporal and spatial control of ligand vs. receptor results in two different mechanisms governing vascular patterning. Interactions with other transmembrane proteins such as neuropilin and VEGFR2 result in different axonal behaviors. Ligand receptor localization on pre- vs. post-synaptic neurons is used to control different types of synapse formation. Perhaps different downstream effectors will also result in different functional outcomes. Given the limited number of ligands and receptors in the genome and their multifunctional nature, we expect that more modes of action will be discovered in the future. In this review, we highlight current advances on the mechanisms of how Sema3E–Plexin-D1 interaction shapes the networks of multiple biological systems, in particular the vascular and nervous systems.


► Sema3E can bind and signal directly with Plexin-D1, independently of neuropilins.
► Sema3E-Plexin-D1 regulates multiple aspects of neural and vascular development.
► Sema3E–Plexin-D1 controls developmental processes via different mechanisms of actions.
► Different downstream effectors will also result in different functional outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 24, Issue 3, March 2013, Pages 156–162
نویسندگان
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