کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2202858 1100400 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron–glia signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron–glia signaling
چکیده انگلیسی

Studies on the release of ATP from neurons began with the earliest investigations of quantal neurotransmitter release in the 1950s, but in contrast to ATP release from other cells, studies of ATP release from neurons have been narrowly constrained to one mechanism, vesicular release. This is a consequence of the prominence of synaptic transmission in neuronal communication, but nonvesicular mechanisms for ATP release from neurons are likely to have a broader range of functions than synaptic release. Investigations of activity-dependent communication between axons and myelinating glia have stimulated a search for mechanisms that could release ATP from axons and other nonsynaptic regions in response to action potential firing. This has identified volume-activated anion channels as an important mechanism in activity-dependent ATP release from axons, and renewed interest in micromechanical changes in axons that accompany action potential firing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 2, April 2011, Pages 214–219
نویسندگان
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