کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2202881 | 1100401 | 2011 | 6 صفحه PDF | دانلود رایگان |

Calcium (Ca2+) is a fundamental intracellular signalling molecule in neurons. Therefore, significant interest has been expressed in understanding how the dysregulation of Ca2+ signals might impact on neuronal function and the progression of different disease states. Many previous studies have examined the role of Ca2+ in neuronal excitotoxicity and some have started to understand how Ca2+ dysregulation might be a cause or consequence of neurodegeneration. This review will therefore focus on the significance of Ca2+ sensors, proteins that transduce Ca2+ signals, in neuronal function and dysfunction. Finally, we will assess their potential role in neurodegenerative processes, such as Alzheimer's disease (AD), arguing that they could serve as potential therapeutic targets.
► Ca2+ signal dysregulation impairs neuronal function and contributes to neuronal pathology.
► Ca2+ sensors, transducers of Ca2+ signals, are critical in both neuron function and dysfunction.
► We therefore assess the role of Ca2+ sensors in neurodegenerative processes.
► We argue that Ca2+ sensors could serve as potential therapeutic targets.
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 5, July 2011, Pages 530–535