کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2202894 | 1100402 | 2011 | 7 صفحه PDF | دانلود رایگان |
Planar cell polarity, the orientation of single-cell asymmetries within the plane of a multicellular tissue, is essential to generating the shape and dimensions of organs and organisms. Planar polarity systems align cell behavior with the body axes and orient the cellular processes that lead to tissue elongation. Using Drosophila as a model system, significant progress has been made toward understanding how planar polarity is generated by biochemical and mechanical signals. Recent studies using time-lapse imaging reveal that cells engage in a number of active behaviors whose orientation and dynamics translate planar cell polarity into tissue elongation. Here we review recent progress in understanding the cellular mechanisms that link planar polarity to large-scale changes in tissue structure.
► In this review we describe three examples of planar cell polarity in Drosophila.
► Each example presents how dynamic cell behaviors revealed through live imaging lead to tissue elongation.
► We discuss recent studies that highlight mechanical and biochemical signals important for these processes.
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 8, October 2011, Pages 858–864