کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2202975 1100410 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel functions for the anaphase-promoting complex in neurobiology
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Novel functions for the anaphase-promoting complex in neurobiology
چکیده انگلیسی

In recent years, diverse and unexpected neurobiological functions have been uncovered for the major cell cycle-regulated ubiquitin ligase, the anaphase-promoting complex (APC). Functions of the APC in the nervous system range from orchestrating neuronal morphogenesis and synapse development to the regulation of neuronal differentiation, survival, and metabolism. The APC acts together with the coactivating proteins Cdh1 and Cdc20 in neural cells to target specific substrates for ubiquitination and consequent degradation by the proteasome. As we continue to unravel APC functions and mechanisms in neurobiology, these studies should advance our understanding of the molecular mechanisms of neuronal connectivity, with important implications for the study of brain development and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 6, August 2011, Pages 586–594
نویسندگان
, ,