کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2203037 1100414 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone
چکیده انگلیسی

In mammalian cultured cells the initiation of cytokinesis is regulated – both temporally and spatially – by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 21, Issue 3, May 2010, Pages 290–299
نویسندگان
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