کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2203291 1100433 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Imaging mRNA movement from transcription sites to translation sites
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Imaging mRNA movement from transcription sites to translation sites
چکیده انگلیسی

RNA localization is one mechanism to temporally and spatially restrict protein synthesis to specific subcellular compartments in response to extracellular stimuli. To understand the mechanisms of mRNA localization, a number of methods have been developed to follow the path of these molecules in living cells including direct labeling of target mRNAs, the MS2-GFP system, and molecular beacons. We review advances in these methods with the goal of identifying the particular strengths and weaknesses of the various approaches in their ability to follow the movements of mRNAs from transcription sites to translation sites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 18, Issue 2, April 2007, Pages 202–208
نویسندگان
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