کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2204271 | 1100763 | 2016 | 13 صفحه PDF | دانلود رایگان |
Astrocytes are abundant glial cells that tile the entire central nervous system and mediate well-established functions for neurons, blood vessels, and other glia. These ubiquitous cells display intracellular Ca2+ signals, which have been intensely studied for 25 years. Recently, the use of improved methods has unearthed the panoply of astrocyte Ca2+ signals and a variable landscape of basal Ca2+ levels. In vivo studies have started to reveal the settings under which astrocytes display behaviorally relevant Ca2+ signaling. Studies in mice have emphasized how astrocyte Ca2+ signaling is altered in distinct neurodegenerative diseases. Progress in the past few years, fueled by methodological advances, has thus reignited interest in astrocyte Ca2+ signaling for brain function and dysfunction.
TrendsAstrocytes display intracellular Ca2+ signals.Improved methods have unearthed new types of astrocyte Ca2+ signals.Astrocyte basal Ca2+ levels are variable.In vivo studies suggest that astrocytes display behaviorally relevant Ca2+ signaling.Astrocyte Ca2+ signaling is altered in neurodegenerative diseases.
Journal: - Volume 26, Issue 4, April 2016, Pages 300–312