کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204335 1100770 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Post-translational modifications of tubulin: pathways to functional diversity of microtubules
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Post-translational modifications of tubulin: pathways to functional diversity of microtubules
چکیده انگلیسی


• Tubulin modifications contribute to functional diversity of microtubules (MTs).
• Post-translational modifications (PTMs) affect MT dynamics, organization, and interactions with other cellular components.
• Various PTMs overlap or localize to specific MT domains demonstrating heterogeneity.
• PTMs vary with time, cell type, subcellular compartment, and physiological state.

Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 25, Issue 3, March 2015, Pages 125–136
نویسندگان
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