کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2204411 | 1100777 | 2014 | 9 صفحه PDF | دانلود رایگان |
• The N-end rule targets protein substrates for ubiquitin-mediated degradation via their amino-termini.
• The pathway regulates functionally diverse substrates and processes in eukaryotes.
• Almost all protein amino-termini can impact on protein stability.
• Oxygen and NO sensing are mediated by the N-end rule through kingdom-specific substrates.
The N-end rule pathway of targeted proteolysis, which relates the stability of a protein to the nature of its N-terminus, has emerged as a key regulator of diverse processes in eukaryotes. Recent reports that N-terminally acetylated and methionine-initiating proteins can be targeted for degradation have uncovered novel branches of the pathway, and a wide range of protein substrates has now been identified in animals, fungi, and plants. Of particular interest is the finding that the N-end rule pathway mediates oxygen and nitric oxide (NO) sensing in plants and animals by controlling the stability of kingdom-specific substrates. These findings highlight how conserved degradation mechanisms of the N-end rule pathway underlie functional divergence throughout eukaryotes.
Journal: - Volume 24, Issue 10, October 2014, Pages 603–611