کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204411 1100777 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions
ترجمه فارسی عنوان
مسیر قاعده ی نهایی یوکاریوتی: مکانیسم های حفظ شده و توابع متنوع
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• The N-end rule targets protein substrates for ubiquitin-mediated degradation via their amino-termini.
• The pathway regulates functionally diverse substrates and processes in eukaryotes.
• Almost all protein amino-termini can impact on protein stability.
• Oxygen and NO sensing are mediated by the N-end rule through kingdom-specific substrates.

The N-end rule pathway of targeted proteolysis, which relates the stability of a protein to the nature of its N-terminus, has emerged as a key regulator of diverse processes in eukaryotes. Recent reports that N-terminally acetylated and methionine-initiating proteins can be targeted for degradation have uncovered novel branches of the pathway, and a wide range of protein substrates has now been identified in animals, fungi, and plants. Of particular interest is the finding that the N-end rule pathway mediates oxygen and nitric oxide (NO) sensing in plants and animals by controlling the stability of kingdom-specific substrates. These findings highlight how conserved degradation mechanisms of the N-end rule pathway underlie functional divergence throughout eukaryotes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 24, Issue 10, October 2014, Pages 603–611
نویسندگان
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