کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2204526 | 1100794 | 2012 | 6 صفحه PDF | دانلود رایگان |
Skeletal muscle is formed by the iterative fusion of precursor cells (myocytes) into long multinuclear fibres. Extensive studies of fusion in Drosophila embryos have lead to a paradigm in which myoblasts are divided into two distinct subtypes – founder and fusion-competent myoblasts (FCMs) – that can fuse to each other, but not among themselves. Only founder cells can direct the formation of muscle fibres, while FCMs act as a cellular substrate. Recent studies in zebrafish and mice have demonstrated conservation of the molecules originally identified in Drosophila, but an important question remains: is vertebrate fusion regulated by specifying myocyte subtypes? Stated simply: do vertebrate founder cells exist? In light of recent findings, we argue that a different regulatory mechanism has evolved in vertebrates.
Journal: - Volume 22, Issue 8, August 2012, Pages 391–396