کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204561 1100796 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Directing the assembly of spatially organized multicomponent tissues from the bottom up
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Directing the assembly of spatially organized multicomponent tissues from the bottom up
چکیده انگلیسی

The complexity of the human body derives from numerous modular building blocks assembled hierarchically across multiple length scales. These building blocks, spanning sizes ranging from single cells to organs, interact to regulate development and normal organismal function but become disorganized during disease. Here, we review methods for the bottom-up and directed assembly of modular, multicellular, and tissue-like constructs in vitro. These engineered tissues will help refine our understanding of the relationship between form and function in the human body, provide new models for the breakdown in tissue architecture that accompanies disease, and serve as building blocks for the field of regenerative medicine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 22, Issue 12, December 2012, Pages 683–691
نویسندگان
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