کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204623 1100803 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Perilous journey: a tour of the ubiquitin–proteasome system
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Perilous journey: a tour of the ubiquitin–proteasome system
چکیده انگلیسی


• E2s and E3s work together to catalyze the transfer of ubiquitin to substrate.
• The rate of ubiquitin transfer to the substrate governs its proteasomal degradation.
• Ubiquitinated substrates induce large conformational changes in the proteasome.

Eukaryotic cells are equipped to degrade proteins via the ubiquitin–proteasome system (UPS). Proteins become degraded upon their conjugation to chains of ubiquitin where they are then directed to the 26S proteasome, a macromolecular protease. The transfer of ubiquitin to proteins and their subsequent degradation are highly complex processes, and new research is beginning to uncover the molecular details of how ubiquitination and degradation take place in the cell. We review some of the new data providing insights into how these processes occur. Although distinct mechanisms are often observed, some common themes are emerging for how the UPS guides protein substrates through their final journey.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 24, Issue 6, June 2014, Pages 352–359
نویسندگان
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