کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204777 1100820 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
چکیده انگلیسی

Intact synaptic homeostasis is a fundamental prerequisite for a healthy brain. Thus, it is not surprising that altered synaptic morphology and function are involved in the molecular pathogenesis of so-called synaptopathies including autism, schizophrenia (SCZ) and Alzheimer's disease (AD). Intriguingly, various recent studies revealed a crucial role of postsynaptic ProSAP/Shank scaffold proteins in all of the aforementioned disorders. Considering these findings, we follow the hypothesis that ProSAP/Shank proteins are key regulators of synaptic development and plasticity with clear-cut isoform-specific roles. We thus propose a model where ProSAP/Shank proteins are in the center of a postsynaptic signaling pathway that is disrupted in several neuropsychiatric disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 10, October 2011, Pages 594–603
نویسندگان
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