کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204805 1100824 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The endoplasmic reticulum and protein trafficking in dendrites and axons
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The endoplasmic reticulum and protein trafficking in dendrites and axons
چکیده انگلیسی

Neurons are highly polarized cells whose dendrites and axons extend long distances from the cell body to form synapses that mediate neuronal communication. The trafficking of membrane lipids and proteins throughout the neuron is essential for the establishment and maintenance of cell morphology and synaptic function. However, the dynamic shape and spatial organization of secretory organelles, and their role in defining neuronal polarity and the composition of synapses, are not well delineated. In particular, the structure and function of the continuous and intricate network of the endoplasmic reticulum (ER) in neurons remain largely unknown. Here we review our current understanding of the ER in dendrites and axons, its contribution to local trafficking of neurotransmitter receptors, and the implications for synaptic plasticity and pathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 4, April 2011, Pages 219–227
نویسندگان
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