کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2204815 | 1100825 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Histone ADP-ribosylation in DNA repair, replication and transcription Histone ADP-ribosylation in DNA repair, replication and transcription](/preview/png/2204815.png)
Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has often been restricted to functions of the modifying enzymes, rather than to histones as ADP-ribose acceptors. In particular, the identification of specific lysine residues as ADP-ribose acceptor sites in histones and the identification of ADP-ribose binding modules raise this modification to a par with acetylation, methylation or phosphorylation. We discuss here the functional aspects of histone ADP-ribosylation and its influence on DNA repair, replication and transcription.
Journal: - Volume 21, Issue 9, September 2011, Pages 534–542