کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204890 1100839 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Endoplasmic and sarcoplasmic reticulum in the heart
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Endoplasmic and sarcoplasmic reticulum in the heart
چکیده انگلیسی

The concept of the presence of sarcoplasmic reticulum (SR) membrane in the heart is widely accepted and has been considered merely to be a different name for the endoplasmic reticulum (ER) in muscle tissues. Cardiac SR membranes are specialized in the regulation of Ca2+ transport and control of excitation–contraction coupling. By contrast, the ER is responsible for protein synthesis, modification, secretion, lipid and steroid synthesis, and modulation of Ca2+ signaling. Recent developments have indicated that functional changes in proteins or pathways normally associated with ER and not SR membrane impact cardiac development and pathology. Here, we propose that the SR and ER might be functionally distinct internal membrane compartments in cardiomyocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 6, June 2009, Pages 253–259
نویسندگان
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