کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204894 1100839 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration
چکیده انگلیسی

Muscle regeneration provides a paradigm by which to study how extrinsic signals coordinate gene expression in somatic stem cells (satellite cells) by directing the genome distribution of chromatin-modifying complexes. Understanding the signal-dependent control of the epigenetic events underlying the transition of muscle stem cells through sequential regeneration stages holds the promise to reveal new targets for selective interventions toward repairing diseased muscles. This review describes the latest findings on how regeneration cues are integrated at the chromatin level to build the transcription network that regulates progression of endogenous muscle progenitors throughout the myogenic program. In particular, we describe how specific epigenetic signatures can confer responsiveness to extrinsic cues on discrete regions of the muscle stem cell genome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 6, June 2009, Pages 286–294
نویسندگان
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