کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2204912 | 1100841 | 2009 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Crosstalk in Met receptor oncogenesis Crosstalk in Met receptor oncogenesis](/preview/png/2204912.png)
The Met receptor tyrosine kinase (RTK) regulates several distinct biological processes, including cell scatter, cell invasion, cell survival and epithelial remodeling. MET is genetically altered through several mechanisms in multiple human cancers; these events are causally related to cancer initiation and progression, identifying Met as a potential therapeutic target. Recent evidence highlights additional roles for Met in cancer through crosstalk with other receptors and cell surface proteins. In this review, we discuss recent progress in our understanding of mechanisms of interaction between Met, the epidermal growth factor receptor family and other cell surface protein families, and how these contribute to signal crosstalk, oncogenesis and drug resistance.
Journal: - Volume 19, Issue 10, October 2009, Pages 542–551