کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2204916 | 1100842 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Is HAP2-GCS1 an ancestral gamete fusogen? Is HAP2-GCS1 an ancestral gamete fusogen?](/preview/png/2204916.png)
Eukaryotes employ a diversity of strategies to ensure that gametes come together, but the cellular climax is less varied: gamete plasma membranes must fuse to allow the combination of parental genomes. Recent studies of HAP2-GCS1, a sex-restricted transmembrane protein found in genomes representing all major eukaryotic taxa except fungi, suggest that a broad array of eukaryotic organisms could share a common mechanism for gamete fusion. Plant, protozoan, and algal gametes carrying loss-of-function mutations in HAP2-GCS1 fail to fuse with their complements. We propose that HAP2-GCS1 is a crucial component of an ancient mechanism that mediates the fusion of gamete plasma membranes and could have been a key early innovation in the evolution of sexual reproduction.
Journal: - Volume 20, Issue 3, March 2010, Pages 134–141