کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204971 1100847 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
To localize or not to localize: mRNA fate is in 3′UTR ends
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
To localize or not to localize: mRNA fate is in 3′UTR ends
چکیده انگلیسی

Translation of localized mRNA is a fast and efficient way of reacting to extracellular stimuli with the added benefit of providing spatial resolution to the cellular response. The efficacy of this adaptive response ultimately relies on the ability to express a particular protein at the right time and in the right place. Although mRNA localization is a mechanism shared by most organisms, it is especially relevant in highly polarized cells, such as differentiated neurons. 3′-Untranslated regions (3′UTRs) of mRNAs are critical both for the targeting of transcripts to specific subcellular compartments and for translational control. Here we review recent studies that indicate how, in response to extracellular cues, nuclear and cytoplasmic remodeling of the 3′UTR contributes to mRNA localization and local protein synthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 9, September 2009, Pages 465–474
نویسندگان
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