کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205003 1100851 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functions and molecular mechanisms of the CD47–SIRPα signalling pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Functions and molecular mechanisms of the CD47–SIRPα signalling pathway
چکیده انگلیسی

Signal regulatory protein (SIRP)α, also known as SHPS-1 or SIRPA, is a transmembrane protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is predominantly expressed in neurons, dendritic cells and macrophages. CD47, a widely expressed transmembrane protein, is a ligand for SIRPα, with the two proteins constituting a cell–cell communication system. The interaction of SIRPα with CD47 is important for the regulation of migration and phagocytosis. Recent studies have implicated the CD47–SIRPα signalling pathway in immune homeostasis and in regulation of neuronal networks. Advances in the structural and functional analyses of the CD47–SIRPα signalling pathway now provide exciting hints of the therapeutic benefits of manipulating this signalling system in autoimmune diseases and neurological disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 2, February 2009, Pages 72–80
نویسندگان
, , , ,