کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205020 1100853 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Message in a bottle: long-range retrograde signaling in the nervous system
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Message in a bottle: long-range retrograde signaling in the nervous system
چکیده انگلیسی

In many regions of the nervous system, signals produced by target cells and surrounding glia or in response to injury are received at axon terminals and then retrogradely propagated to cell bodies where they regulate gene transcription and other cellular processes required for development and adult function. The cellular and molecular mechanisms of axonal retrograde signaling in neurons have traditionally been studied in the context of survival signals provided by target-derived neurotrophic factors, in which signaling endosomes containing endocytosed ligand–receptor complexes and downstream effectors are retrogradely transported by dynein motors. In recent years, this notion has been refined and additional mechanisms for long-range retrograde signaling in axons have been described. This article discusses some outstanding issues in the signaling endosome hypothesis as well as recent findings suggesting the existence of a variety of mechanisms for the retrograde propagation of signals in the nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 11, November 2007, Pages 519–528
نویسندگان
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