کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205040 1100855 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development
چکیده انگلیسی

The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 1, January 2009, Pages 16–23
نویسندگان
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