کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2205041 | 1100855 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: CGH-1 and the control of maternal mRNAs CGH-1 and the control of maternal mRNAs](/preview/png/2205041.png)
Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to P-bodies and stress granules, which are conserved RNP granules seen in somatic cells. In addition, a highly conserved putative RNA helicase, termed CGH-1 in C. elegans, is now shown to be important for both for translation repression and the stability of stored mRNAs. The analysis of CGH-1 ortholog functions in somatic cells and its interacting proteins indicate possible mechanisms by which this protein family might stabilize stored maternal mRNAs.
Journal: - Volume 19, Issue 1, January 2009, Pages 24–28