کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205048 1100856 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms for maintaining microtubule bundles
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Mechanisms for maintaining microtubule bundles
چکیده انگلیسی

The dynamics of microtubules (MTs) are crucial to many of their functions. Certain MT structures, such as the mitotic spindle apparatus, exhibit high MT turnover yet maintain their mass stably through long periods of time. Here, we highlight what are emerging as two important mechanisms for maintaining MT bundles: the first, MT nucleation from pre-existing MTs by means of γ-tubulin-containing complexes; and the second, MT ‘rescue’ by the stabilizing protein CLASP. As examples, we describe recent advances in understanding the assembly and maintenance of simple MT bundles in fission yeast and plant cells, which have implications for the bundles of the animal mitotic spindle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 12, December 2008, Pages 580–586
نویسندگان
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