کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205069 1100858 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies
چکیده انگلیسی

The N-end rule states that the half-life of a protein is determined by the nature of its N-terminal residue. This fundamental principle of regulated proteolysis is conserved from bacteria to mammals. Although prokaryotes and eukaryotes employ distinct proteolytic machineries for degradation of N-end rule substrates, recent findings indicate that they share common principles of substrate recognition. In eukaryotes substrate recognition is mediated by N-recognins, a class of E3 ligases that labels N-end rule substrates via covalent linkage to ubiquitin, allowing the subsequent substrate delivery to the 26S proteasome. In bacteria, the adaptor protein ClpS exhibits homology to the substrate binding site of N-recognin. ClpS binds to the destabilizing N-termini of N-end rule substrates and directly transfers them to the ClpAP protease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 4, April 2007, Pages 165–172
نویسندگان
, , ,