کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2205081 | 1100859 | 2008 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Structure, dynamics and function of nuclear pore complexes Structure, dynamics and function of nuclear pore complexes](/preview/png/2205081.png)
Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure.
Journal: - Volume 18, Issue 10, October 2008, Pages 456–466