کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205133 1100864 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The VAP protein family: from cellular functions to motor neuron disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The VAP protein family: from cellular functions to motor neuron disease
چکیده انگلیسی

The VAMP-associated proteins (VAPs) are highly conserved integral endoplasmic reticulum membrane proteins implicated in diverse cellular functions, including the regulation of lipid transport and homeostasis, membrane trafficking, neurotransmitter release, stabilization of presynaptic microtubules, and the unfolded protein response. Recently, a single missense mutation within the human VAP-B gene was identified in three forms of familial motor neuron disease. In this review, we integrate results from studies of yeast, fly and mammalian VAPs that provide insight into the structural features of these proteins, the network of VAP-interacting proteins, their possible physiological functions, and their involvement in motor neuron disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 6, June 2008, Pages 282–290
نویسندگان
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