کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205134 1100864 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions
چکیده انگلیسی

Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. Although HDAC6 enzymatic activity seems to be required for the regulation of cell morphology, the role of HDAC6 in lymphocyte chemotaxis is independent of its tubulin deacetylase activity. The diverse functions of HDAC6 suggest that it is a potential therapeutic target for the treatment of a range of diseases. This review examines the biological actions of HDAC6, focusing on its deacetylase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 6, June 2008, Pages 291–297
نویسندگان
, , , ,