کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205160 1100866 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects
چکیده انگلیسی

During the development of the nervous system and other organs in the embryo, a limited set of master signaling pathways are used repeatedly for induction, patterning and growth. Among these, the Sonic hedgehog (Shh) pathway is crucial for the development of many structures in the brain. How the context-specific interplay between these various signaling pathways produces distinct temporal and spatial outcomes is not clear. Resolving this problem is a major goal in the study of cell and organ development. Here, we focus on signaling events during dorso-ventral patterning of the embryonic forebrain in vertebrates. In particular, we discuss the role of the Shh pathway in this process and on its interactions with the FGF, retinoic acid and Nodal pathways and other information cascades that modify its effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 11, November 2006, Pages 597–605
نویسندگان
, ,