کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205184 1100869 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Wires in the soup: quantitative models of cell signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Wires in the soup: quantitative models of cell signaling
چکیده انگلیسی

Living cells are capable of extracting information from their environments and mounting appropriate responses to a variety of challenges. The underlying signal transduction networks enabling this response can be quite complex, and so sophisticated computational modeling coupled with precise experimentation is required to unravel them. Although we are still at the beginning of this process, some recent examples of integrative analysis of cell signaling are very encouraging. Quantitative models of signaling pathways (e.g. NF-κB) can be gradually constructed through continuous experimental validation, and important lessons can be learnt from such exercises.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 3, March 2008, Pages 112–118
نویسندگان
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