کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205208 1100871 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
14-3-3 proteins: regulation of endoplasmic reticulum localization and surface expression of membrane proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
14-3-3 proteins: regulation of endoplasmic reticulum localization and surface expression of membrane proteins
چکیده انگلیسی

The density and composition of cell surface proteins are major determinants for cellular functions. Regulation of cell surface molecules occurs at several levels, including the efficiency of surface transport, and is therefore of great interest. As the major phosphoprotein-binding modules, 14-3-3 proteins are known for their crucial roles in a wide range of cellular activities, including the subcellular localization of target proteins. Accumulating evidence suggests a role for 14-3-3 in surface transport of membrane proteins, in which 14-3-3 binding reduces endoplasmic reticulum (ER) localization, thereby promoting surface expression of membrane proteins. Here, we focus on recent evidence of 14-3-3-mediated surface transport and discuss the possible molecular mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 7, July 2006, Pages 370–375
نویسندگان
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