کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205302 1100886 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential arginylation of actin isoforms: the mystery of the actin N-terminus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Differential arginylation of actin isoforms: the mystery of the actin N-terminus
چکیده انگلیسی

Actin is one of the most abundant, essential and well studied intracellular proteins, yet its regulation in vivo is still not completely understood. One of the mysteries around actin concerns the existence of multiple actin isoforms that are extremely similar to each other except for their N-termini but have been shown in multiple studies to preferentially incorporate into different actin networks and are suggested to have different roles in vivo. The mechanisms of this actin isoform segregation are unknown. My colleagues and I recently showed that β but not γ actin in cultured fibroblasts undergoes N-terminal arginylation, which regulates actin polymerization and lamella formation in motile cells. Here, I propose that arginylation could be a general mechanism that regulates actin isoform segregation in vivo and participates in the formation of loose β-actin network at the leading edge of the cell.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 12, December 2006, Pages 610–615
نویسندگان
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