کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205312 1100887 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control
چکیده انگلیسی

In recent years, a link between the transcriptional regulators of lineage-specific gene expression and progenitor proliferation control has emerged. A main exponent of this phenomenon is the CCAAT/enhancer binding protein (C/EBP) family of basic region-leucine zipper proteins. These transcription factors control the differentiation of a range of cell types, and have key roles in regulating cellular proliferation through interaction with cell cycle proteins. More recently, their position at the crossroads between proliferation and differentiation has made them strong candidate regulators of tumorigenesis, and C/EBPs have been described as both tumor promoters and tumor suppressors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 7, July 2007, Pages 318–324
نویسندگان
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