کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2205370 1100905 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Wnt canon orchestrating osteoblastogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
A Wnt canon orchestrating osteoblastogenesis
چکیده انگلیسی

Several transcription factors have been identified that control the differentiation of osteoblasts; however, relatively little is known about the signaling pathways involved in regulating the differentiation process. Recently, the canonical Wnt–β-catenin pathway has been implicated in osteoblastogenesis. This review focuses on the role of the canonical Wnt–β-catenin pathway during embryonic development, where it is required for the differentiation of osteoblasts from a precusor that is shared with the chondrocyte lineage and the requirement of this pathway during postnatal life in bone homeostasis. The recent findings covered in this review are major advances in our understanding of skeletal development and promise new therapeutic avenues for tissue engineering and treatment of osteoporosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 3, March 2006, Pages 151–158
نویسندگان
,