کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2205371 | 1100905 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pathways and control of connexin oligomerization Pathways and control of connexin oligomerization](/preview/png/2205371.png)
Connexins form gap junction channels that link neighboring cells into an intercellular communication network. Many cells that express multiple connexins produce heteromeric channels containing at least two connexins, which provides a means to fine tune gap junctional communication. Formation of channels by multiple connexins is controlled at two levels: by inherent structural compatibilities that enable connexins to hetero-oligomerize and by cellular mechanisms that restrict the formation of heteromers by otherwise compatible connexins. Here, I discuss roles for secretory compartments beyond the endoplasmic reticulum in connexin oligomerization and evidence that suggests that membrane microdomains help regulate connexin trafficking and assembly.
Journal: - Volume 16, Issue 3, March 2006, Pages 159–166