Mathematical model and experimental validation of the synergistic effect of selective enantioseparation of (S)-amlodipine from pharmaceutical wastewater using a HFSLM

A case study on the synergistic enantioseparation of (S)-amlodipine from pharmaceutical wastewater by using hollow fiber supported liquid membrane (HFSLM) was examined. A chiral reaction flux mathematical model was applied. Optimum conditions achieved the highest percentages of extraction and stripping viz. 84% and 80%, respectively. Relevant parameters affecting the enantioseparation efficiency of (S)-amlodipine were determined. Standard deviation percentages were 2.31% for extraction and 1.26% for stripping. It was found that the mathematical model proved to be in good agreement with the experimental data.

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