کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
228134 | 464835 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel process for preparing pure chenodeoxycholic acid from poultry bile
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Macroporous adsorption by column chromatography was introduced into chenodeoxycholic acid (CDCA) separation from duck bile in this study. After bile saponification in 2.5 M NaOH for 6 h and conversion of CDCA calcium salt with Na2CO3, CDCA was purified by the hydrophobic chromatography with macroporous resin HZ-802. With 40% ethanol as loading solvent and 50% and 60% ethanol as stage elution solvents, high purity of CDCA was obtained, and its melting point could be achieved 160–170 °C (99% purity) after crystallization by 65–70 °C water bath cultivation. The novel process was environmentally friendly and economical compared to conventional method, and it has been successfully scaled up in industry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Industrial and Engineering Chemistry - Volume 18, Issue 1, 25 January 2012, Pages 65–71
Journal: Journal of Industrial and Engineering Chemistry - Volume 18, Issue 1, 25 January 2012, Pages 65–71
نویسندگان
Junfen Wan, Jiemin He, Xuejun Cao,