کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
229418 465027 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Noval 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazole derivatives: Synthesis and pharmacological activity
ترجمه فارسی عنوان
نوال 1-جایگزین-3،5-دی متیل-4 - [(جایگزین فنیل) دیازینیل] متیل پریازول: سنتز و فعالیت های دارویی
کلمات کلیدی
پریازول، ضد التهابی زخم معده، پراکسیداسیون لیپید، اثر هپاتوتوکسیک
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی

Several-1-carbothioamide-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 2a–d, 1-(pyridine-4-ylcarbonyl)-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 3a–d, 1-(5-chloro-6-fluoro-1,3-benzothiazole-2-yl)thiocarbamoyl-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 4a–d and 1-[(1,2,4-triazole-4-yl) carbothioamide]-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 5a–d were synthesized. The structures of the newly synthesized compounds were supported by IR, 1H NMR and mass spectral data. These compounds were investigated for their, anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, antibacterial and antifungal activities. Some of the synthesized compounds showed potent anti-inflammatory activity along with minimal ulcerogenic effect and lipid peroxidation, compared to ibuprofen and flurbiprofen. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 19, Issue 3, May 2015, Pages 274–281
نویسندگان
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