Synthesis and characterization of some pyrimidine–quinoline clubbed molecules and their microbicidal efficacy

The required chalcones 1a–h were prepared by reaction of aryl acetophenone with different aryl aldehydes, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamines 2a–h. Novel pyrimidine–quinoline clubbed molecules 3a–h have been prepared by reaction of 2a–h with 4-chloro-2,6-dimethylquinoline. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.