Molecular modeling of 8-methoxy quinolone analogues by using quantitative structure activity relationship

Quantitative structure activity relationship (QSAR) studies on a series of 8-methoxy quinolone are found to correlate well with steric parameters and electronic parameter. The results are critically discussed on the basis of regression data, Pogliani factor Q and cross validation technique. The results are found to be useful in discussing the mechanism of drug – receptor interaction. Steric parameter ‘Mr’ and electronic parameter ‘Pz’ gives the best model.