Supercritical Assisted Atomization of emulsions for encapsulation of 1-monoacylglycerols in an hydrophilic carrier

• Production of microparticles from O/W emulsions by SAA was performed for the first time, using 1-MAG/PVA as model compounds.
• Properties of emulsion were affected by the preparation method (high speed stirring, sonication).
• 1-MAG/PVA ratio and emulsification method influenced size, and distribution of micronized particles.
• The highest recovery of the powder (50–60%) was found in emulsions containing 20 or 30 mg/mL 1-MAG.
• 1-MAG/PVA microparticles were semi-crystalline, spherically shaped with the size of 0.5–3 μm.

A new approach for the production of microspheres from oil-in-water (O/W) emulsions using supercritical fluids is presented. The composition of the emulsions, consisting of 1-monoacylglycerol (1-MAG) and polyvinylalcohol (PVA) was first optimized, then supercritical assisted atomization (SAA) was applied to produce dried microparticles. The effect of different 1-MAG/PVA ratios and emulsion preparation method on size, stability, and morphology of microparticles was investigated using scanning electron microscopy, dynamic light scattering, differential scanning calorimetry and X-ray diffraction. The emulsion composition and emulsification method affected the sizes of microparticles and the smallest 1-MAG/PVA microparticles were obtained at lower 1-MAG (<30 mg/mL) and PVA (6 mg/mL) concentrations. Prepared 1-MAG/PVA microparticles had a spherical morphology with mean diameter ranging from 0.5 to 3 μm and a semi-crystalline structure. A maximum microparticle recovery of 55% was obtained.

Figure optionsDownload as PowerPoint slide