کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
230578 1427389 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dissolution rate enhancement of the anti-inflammatory drug diflunisal by coprecipitation with a biocompatible polymer using carbon dioxide as a supercritical fluid antisolvent
ترجمه فارسی عنوان
افزایش میزان رقیق شدن داروهای ضد التهابی توسط دی اکسید کربن با استفاده از پلیمر زیست سازگار با استفاده از دی اکسید کربن به عنوان یک ضد حلال مایع فوق بحرانی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی


• Supercritical fluid antisolvent (SAS) micronization is used to obtain diflunisal and diflunisal/PVP K-30 composites.
• Composites exhibit spherical morphologies with diameters ranging from 0.4 to 8 μm.
• Crystallinity, compositions, drug-polymer interactions, and drug release are studied.
• Application of SAS to the pure drug leads to a change in its polymorphic form.
• Diflunisal dissolution rate enhancement is attained using PVP in conjunction with SAS.

Dissolution rate enhancement of the anti-inflammatory drug diflunisal was achieved using for the first time a supercritical fluid technology. The supercritical fluid antisolvent (SAS) method was applied to precipitate diflunisal alone and to coprecipitate the drug together with the biocompatible polymer polyvinylpyrrolidone (PVP K-30 and K-10). The untreated and SAS processed diflunisal, and the coprecipitates were characterized in terms of size, morphology, crystallinity, compositions, drug-polymer interactions, and drug release. SAS processed diflunisal exhibited a polymorphic form different from that of the untreated drug. Diflunisal crystallinity disappeared in the coprecipitates. Three different drug: polymer mass ratios were studied: 75:25, 50:50, and 25:75. Microparticle size decreased and aggregation disappeared as the relative amount of polymer increased. The 25:75 coprecipitate consisted of loose spherical particles exhibiting mean particle size of 410 nm while the 75:25 coprecipitate consisted of bigger aggregated particles. The SAS method was shown to be a suitable technology to form solid dispersions of a poorly soluble drug.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Supercritical Fluids - Volume 88, April 2014, Pages 56–65
نویسندگان
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