Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles

Nanoparticles are used for a number of biomedical applications. In this work we report the synthesis of folic acid (FA) modified polyethylene glycol (PEG) functionalized hydroxyapatite (HAp) nanoparticles. The anticancer drug, paclitaxel, is attached to the folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles and the in vitro drug release is analyzed. The surface modification and functionalization is confirmed by Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA) and UV spectroscopy. The importance of the paper is the investigation of the release behavior of paclitaxel conjugated folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. The results show an initial rapid release and then a sustained release.

Hydroxyapatite is used for targeted drug delivery. Paclitaxel is attached to the surface modified hydroxyapatite nanoparticles. A controlled delivery of paclitaxel in vitro is observed.Figure optionsDownload as PowerPoint slideHighlights
► Hydroxyapatite, the biocompatible material, is used for targeted drug delivery.
► Surface is modified with polyethylene glycol.
► Folic acid is used as the ligand to target folate receptor.
► Paclitaxel is attached to the surface modified hydroxyapatite nanoparticles.
► A controlled delivery of paclitaxel in vitro is observed.