کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
236706 465682 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of spray-dried chitosan microcarriers for nanoparticle delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Development of spray-dried chitosan microcarriers for nanoparticle delivery
چکیده انگلیسی

The design of chitosan microspheres for the encapsulation and release of nanoparticles has been considered. The composite microcarriers have been produced by spray drying and the effect of factors including the chitosan cross-linking ratio (using tri-polyphosphate as the cross-linking agent), nanoparticle loading in the polymer matrix and the internal structure of the microspheres (uniform dispersion of nanoparticles vs. core-shell structure) on the in vitro release kinetics have been systematically investigated. The antibacterial performance of the composite microspheres containing Ag nanoparticles has been evaluated against three different strains of bacteria in a suspension culture. The bioadhesive character of the chitosan carrier particles has lead to the formation of stable aggregates with the bacteria, which enhanced the antibacterial efficacy of the released nanoparticles through the contact mechanism.

Figure optionsDownload as PowerPoint slideHighlights
► Cross-linked chitosan microparticles produced by spray drying
► Encapsulation and release kinetics of nanoparticles investigated
► Release rate influenced by addition of soluble porogen into chitosan matrix
► Antibacterial performance of nanoparticles enhanced by adhesion

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Powder Technology - Volume 235, February 2013, Pages 797–805
نویسندگان
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