کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
237442 | 465707 | 2011 | 5 صفحه PDF | دانلود رایگان |

Earlier work showed that a batch of microcrystalline cellulose (MCC, Avicel PH102) exhibited minimum acceptable flow properties required for successful high speed tableting. The aim of this work was to assess the suitability of using Avicel PH102 as a reference indicator of minimum powder flow by examining the reproducibility of flow properties of seven batches of Avicel PH102. Powder flow properties have been characterized in terms of flow function, flow factor, cohesion, bulk density, effective angle of internal friction, angle of linearized yield locus, and angle of internal friction at steady-state flow. Results show that the measured flow function is independent of operator. Batch-to-batch flow functions are not statistically different at 95% confidence level suggesting acceptable reproducibility. These results corroborate that Avicel PH102 may be used as a reference powder for predicting flow performance of a new formulation during high speed tableting.
Flow properties of Avicel PH102 have been thoroughly characterized using a shear cell. The batch-to-batch reproducibility of the flow properties is acceptable for Avicel PH102 to be used as a reference powder for predicting powder flow behavior during high speed tableting.Figure optionsDownload as PowerPoint slideResearch highlights
► Thorough characterization of flow properties of Avicel PH102 using an annular shear cell.
► Batch-to-batch reproducibility of the flow properties of Avicel PH102 is acceptable.
► It is reasonable to use Avicel PH102 as a reference material for high speed tableting.
Journal: Powder Technology - Volume 212, Issue 1, 15 September 2011, Pages 253–257