کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
239002 465789 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of continuous convective powder mixing processes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Characterization of continuous convective powder mixing processes
چکیده انگلیسی

The Process Analytical Technology (PAT) initiative has encouraged the development of new technology to improve upon the current manufacturing paradigm. As a result substantial attention has recently focused on continuous processing due to the ability to control disturbances online, avoiding the loss of processing materials and enabling effective process scale-up. In this paper, a pharmaceutical formulation is blended using a continuous flow “high shear” mixer utilizing different operating and design parameters. The mixing efficiency is characterized by extracting samples at the discharge of the blender, and analyzing them using Near Infrared Spectroscopy to determine compositional distribution. Operational conditions such as the inclination angle of the mixer and impeller rotation rate were investigated and showed to affect the mean residence time. The effects of mixer angle, agitation speed, number of blades, blade angle, number of passes through the mixer on the mixing performance of a powder continuous convective mixer are also examined and shown to affect mixing performance whereas the cohesive properties of the material did not significantly affect the mixing operation.

In this paper, a pharmaceutical formulation is blended using a continuous flow “high shear” mixer utilizing different operating and design parameters. The mixing efficiency is characterized by extracting samples at the discharge of the blender, and analyzing them using Near Infrared Spectroscopy to determine compositional distribution. A number of operational and design parameters are investigated including the effects of inclination angle of the mixer and impeller rotation rate.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Powder Technology - Volume 182, Issue 3, 10 March 2008, Pages 368–378
نویسندگان
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